I can't find [their studies].
I do have access to medical and nutrition journals - they are all online, and anyone can access them for about $8 per article - and I still can't find this report.
Nothing from Hirsch and Leibel in 1950s or 1960s.
I have just basic questions about the study - how big was the study (how many people tested) etc - but I can't find that out without finding the original report.
Have you read it?
Via the blog
I first came across the study two years ago, and was able to find it online for you to peruse -- be sure to download the PDF, rather than simply read the abstract.
In summary, Hirsch and Leibel published a paper in 1992 in the American Journal of Clinical Nutrition, in which they reviewed the records of patients at Rockefeller University's Lipid Laboratory between 1955 and 1965.
They specifically targeted patients -- a total of 16 -- fed different liquid formulas (for at least two weeks) containing an equal amount of calories, but varying fat:carbohydrate ratios.
Although 16 patients might not seem like a very large sample size, the confidence intervals, odds ratios, and power -- a statistical term -- figures of this study demonstrate statistically significant results.
It is worth nothing that none of the patients underwent significant weight changes when their formula was replaced by one of the same caloric amount but a much different (either higher or lower) carbohydrate content.
Gary Taubes has casted off this study as useless in rebutting his argument since none of the patients were obese (he claims to use carbs as the explanation for obesity in individuals already predisposed to it, although that was certainly not made clear in his talk at New York University last month).
Well, Hirsch and Leibel reference several other studies that came to similar conclusions.
Of particular importance is one from 1990 -- also published in the American Journal of Clinical Nutrition -- in which Gilbert Forbes concludes that "although obese individuals appear to deposit a larger proportion of excess intake energy as fat, the energy cost in either lean or obese subjects was not significantly influenced by the composition" of their diet.
Have a slice of whole wheat toast on me tomorrow morning!